A full list of publications can be found in Google Scholar.
(Equal contributions are indicated with "&", and corresponding authors are indicated with "*")
Ji, Y., Chen, X., Wang, Z., Joseph, M.C., McLean, J.L., Yang, Y., Yuan, C., Rochet, J.C., Liu, Fei., and Xu, R*. (2025). Alzheimer’s disease patient brain extracts induce multiple pathologies in novel vascularized neuroimmune organoids for disease modeling and drug discovery. Molecular Psychiatry, 1-18.
Que Z, Olivero-Acosta MI, Chen I, Zhang J, Wettschurack K, Wu J, Xiao T,… Rochet JC, Xu R, Brewster AL, Wu LJ, Yuan C, Skarnes WC, Yang Y. (2024). Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation. Journal of Neuroscience 45 (3).
Ji, Y., Chen, X., Joseph, M.C., McLean, J.L., Yang, Y., Yuan, C., Rochet, J.C., Liu, Fei., and Xu, R*. (2024). Alzheimer’s disease patient brain extracts induce multiple pathologies in vascularized neuroimmune organoids for disease modeling and drug discovery.
bioRxiv link https://www.biorxiv.org/content/10.1101/2024.10.28.620680v1
Wu, J., Zhang, J., Chen, X., Wettschurack, K., Que, Z., . . . Xu, R., Koss, W., Du, D., Chen, F., Wu, L., Yang, Y. (2024). Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids. Molecular Psychiatry 1-14.
Ji, Y., McLean, J.L., Xu, R. *. (2024). Emerging Human PSC-based Human-Animal Brain Chimeras for Advancing Disease Modeling and Cell Therapy for Neurological Disorders. Neuroscience Bulletin 1-18.
Wang, L., Mirabella, V. R., Dai, R., Su, X., Xu, R., Jadali, A., . . . Tian, J. J. M. P. (2022). Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism. Molecular Psychiatry 1-16.
Jin, M., Xu, R., Wang, L., Alam, M.M., Ma, Z., Zhu, S., Martini, A.C., Jadali, A., Bernabucci, M., Xie, P., Kwan, K., Pang, Z.P., Head, E., Liu, Y., Hart, R.P., Jiang, P. (2022). Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer’s disease. Cell Stem Cell 29 (7), 1135-1153. e8
Xu, R.#, Boreland, A.J., Li, X., Erickson, C., Jin, M., Atkins, C., Pang, Z.P., Daniels, B.P., and Jiang, P. (2021). Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology. Stem Cell Reports 16, 1923-1937. (# co-corresponding author)
Jiang, P., Turkalj, L., Xu, R. (2020). High-fidelity modeling of human microglia with pluripotent stem cells. Cell Stem Cell 26 (5), 629-631
Xu, R., X, Li., Boreland, A., Posyton, A., Kwan, K., Hart, R.P., and Jiang, P. (2020). Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain. Nature Communications 11 (1), 1-16
Xu, R., Brawner, A., Li, S., Kim, H., Xue, H., Pang, Z., Kim, W.-Y., Hart, R., Liu, Y., and Jiang, P. (2019). OLIG2 drives abnormal neurodevelopmental phenotypes in human iPSC-based organoid and chimeric mouse models of Down syndrome. Cell Stem Cell 24 (6), 908-926. e8
Kim, H., Xu, R., Ragunathan, P., Dunaevsky, A., Liu, Y., Dreyfus, C., and Jiang, P. (2019). Pluripotent stem cell-derived cerebral organoids reveal human oligodendrogenesis with dorsal and ventral origins. Stem Cell Reports 12 (5), 890-905
Wu, S., Xu, R., Duan, B., and Jiang, P. (2017). Three-dimensional hyaluronic acid hydrogel-based models for in vitro human iPSC-derived NPC culture and differentiation. Journal of Materials Chemistry B 5 (21), 3870-3878
Brawner, A.T., Xu, R., Liu, D., and Jiang, P. (2017). Generating CNS organoids from human induced pluripotent stem cells for modeling neurological disorders. International journal of physiology, pathophysiology and pharmacology 9 (3), 101
Xu, R., Hu, Q., Ma, Q., Liu, C., and Wang, G. (2014). The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway. Cell death & disease 5 (8), e1373
Hu, Q., Li, B., Xu, R., Chen, D., Mu, C., Fei, E., and Wang, G. (2012). The protease Omi cleaves the mitogen-activated protein kinase MEK1 to inhibit microglial activation. Science Signaling. 5 (238), ra61-ra61