Lab News
05-02-2025
The Xu Lab is excited to share that our first research article is online in Molecular Psychiatry.
We developed a vascularized neuroimmune organoid model to study sporadic Alzheimer’s disease (sAD) and accelerate drug discovery, leveraging patient brain extracts. Congratulations to Yanru Ji and other lab members, as well as our collaborators, for this milestone in the lab.
03-20-2025
Summer Research Fellowship 2025
Congratulations to Oliver Johnson on being awarded the competitive Summer Research Fellowship from PVM at Purdue University. Connor will conduct research in the Xu laboratory during the summer.
01-16-2025
New Underagrate Student
The group welcomes Oliver Thomas Johnson to join us as an undergraduate researcher. Welcome to the group!
11-01-2024
New visiting scholar
The group welcomes visiting scholar, Dongkai Guo, to join us ! Welcome to the group!
11-18-2024
Congratulations on a collaborative paper from Dr. Yang Yang's lab at Purdue, recently published in the Journal of Neuroscience! Please check how human iPSC-derived microglia carrying the epilepsy-associated SCN2A-L1342P mutation affect neural activity.
09-18-2024
Our first NIH R21 grant
The Xu lab is excited to receive our first NIH R21 grant. This R21 grant will support us in developing a new human stem cell-based tau model for Alzheimer's disease research in collaboration with Dr. Chris Rochet at Purdue. We appreciate the support from NINDS.
09-09-2024
AD Pre-Clinical Translational Science Grant
We are excited to receive the AD Pre-Clinical Translational Science Grant to support us in developing new therapies for Alzheimer's disease. We appreciate the support from CTSI.
09-06-2024
Our first NIH grant (U01)
The Xu lab is excited to receive our very first NIH grant. This 5-year NIA U01 grant will be led by Dr. Xu(MPI) and Dr. Chongli Yuan(PI), and will focus on the environmental and genetic interactions in Alzheimer's disease using iPSC 2D in vitro model and chimeric brain models. This is an important milestone for the lab. Thank you to the lab for everyone's hard work, and to everyone for your support.
08-15-2024
New Underagrate Student
The group welcomes Akhil Pinnapareddy to join us as an undergraduate researcher. Welcome to the group!
03-18-2024
A new paper from the Dr. Yang Yang lab at Purdue that Dr.Xu collaborated on was recently published in the journal Molecular Psychiatry! Please check the utilization of microglia-containing brain organoids to understand how epilepsy-associated SCN2A-L1342P mutation affects microglial function in development.
03-11-2024
We are excited that our first review paper is online in the Neuroscience Bulletin. https://rdcu.be/dAUNO In it, we discussed recent advances in using human iPSC-based human–animal chimeras to model neurological disease and test cell therapy. Congratulations to Yanru and Jenna!
03-07-2024
Summer Research Fellowship 2024
Congratulations to Connor Meek on being awarded the competitive Summer Research Fellowship from PVM
at Purdue University. Connor will conduct research in the Xu laboratory during the summer.
11-06-2023
New visiting scholar
The group welcomes Xinqi Guo to join us as a visiting scholar! Welcome to the group!
10-06-2023
New Funding
The lab is excited to have received pilot grants from the Purdue Institute for Integrative Neuroscience (PIIN) to develop hiPSC brain organoids for studying Alzheimer's disease and Traumatic brain injury by collaborating with Dr. Chris Rochet, Dr. Riyi Shi and Dr. Jean Chmielewski at Purdue University.
08-25-2023
New Underagrate Students
The group welcomes Raymond Pand and Hongxu Tao to join us as undergraduate researchers. Welcome to the group!
07-25-2023
Showalter Young Investigator 2023
Congratulations to Dr. Ranjie Xu for being awarded the Showalter Trust Research Grant. This grant will support the study to dissect human microglial function in Alzheimer's disease using human iPSC-based microglia models.
05-22-2023
SURF Fellowship 2023
Congratulations to Jenna McLean on being awarded the SURF Fellowship for 2023! Jenna will conduct research in the Xu laboratory during the summer, supported by the SURF program!
01-27-2023
New Underagrate Student
The group welcomes Connor Meek to join us as an undergraduate researcher. Welcome to the group!
01-04-2023
New Graduate Student
The group welcomes Yanru Ji joining us as the first graduate student in the lab! Welcome to the group!
12-16-2022
New Funding
The lab is excited to have received pilot funding from PIIN to develop peptide-induced 3D culture!
11-08-2022
Lab Space Available
Our Lab space in Lynn Hall is available now. The new lab setup will start soon!
10-24-2022
A new paper from the Dr. Zhiping Pang lab that Dr.Xu collaborated on was recently published! Please check how we utilize the human-mouse chimeric brain model to study autism.
09-28-2022
New Undergraduate Students
The group welcomes Lauren Davern and Jenna McLean to join us as an undergraduate researchers. Welcome to the group!
08-15-2022
New Lab Open
Dr. Ranjie Xu joins the Department of Basic Medical Sciences at Purdue University as an assistant professor. The Xu Laboratory officially starts.