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The Xu laboratory works on developing human stem cell models to study the underlying mechanisms of human neurological disorders, such as Alzheimer’s disease, Down Syndrome, and Autism, and apply these models for drug screening. To achieve this, we have developed human stem cell-based 3D in vitro brain organoids and human-mouse chimeric brain models to investigate human neurons, microglia, and neuro-immune interactions in neurological disorders. Furthermore,  we are working on engineering human stem cell-derived neural and immune cells, with the aim of creating innovative cell therapies to treat neurological disorders.

Our group is part of the Department of Basic Medical Sciences, Purdue Institute for Integrative Neuroscience, Purdue Institute of Inflammation, Immunology and Infectious Disease at Purdue University.

Unique human pluripotent stem cells (hPSCs) models established in the lab for

studying human neurological disorders

Diagram of human cells and established hPSC models.tif
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